A replicated soybean study in eastern Nebraska revealed that Vitazyme, as either a seed or a seed plus foliar treatment, significantly improved leaf chlorophyll (2.o to 2.5 SPAD units), main stem nodes (4 to 14%), plant height;main stem node ratios (-0.24 to -0.37), and pods per plant (6 to 56%). Both treat- ments – especially the seed plus foliar treatment – increased the pods distributed along the stem, and slight- ly increased yield and reduced moisture at harvest. The lack of a significant yield response is likely due to a lack of adequate soil fertility to fill the pods that were available to fill as the season progressed. These results show the utility of Vitazyme as a powerful tool for soybean producers in the Corn Belt of the United States.